Derrick Marks scored a career-high 35 points, including 18 straight in the second half, and Boise State upset No. 11 Creighton 83-70 on Wednesday night.
The Broncos (5-1), who played Number 13 Michigan State within four points on the road last week, beat a ranked opponent for the first time in four seasons and on the road for the first time since March 2005.
Creighton (6-1) hadn't lost a regular-season November home game since 1989.
Anthony Drmic had 17 points and Jeff Elorriaga added 12 for the Broncos.
Doug McDermott led Creighton with 21 points and Grant Gibbs added 17.
Boise State led 39-33 after shooting 64 percent from the field the first half. The Broncos made seven straight 3-pointers and were 9 of 13 from beyond the arc in the first 20 minutes, with Elorriaga making 4 of 5.